Curia expands biologics capabilities with access to Touchlight’s doggybone DNA

Curia collaborates with Touchlight to expand its mRNA manufacturing offering to enable access to enzymatic doggybone DNA (dbDNA™)

ALBANY, N.Y. and HAMPTON, United Kingdom, July 24, 2023 (GLOBE NEWSWIRE) — Curia, a leading contract research, development and manufacturing organization, and Touchlight, a company pioneering enzymatic DNA production, today announced an agreement which will provide Curia and its clients a streamlined means of access to Touchlight’s doggybone DNA (dbDNA). The arrangement expands Curia’s mRNA manufacturing offerings with an additional differentiated source of DNA raw material that is immediately available to be accessed by Curia customers. Under the arrangement, Touchlight will directly manufacture dbDNA on behalf of Curia’s customers.

“Curia remains committed to strengthening our biologics offerings and end-to-end mRNA manufacturing capabilities,” said Christopher Conway, President of R&D, Curia. “With the addition of enzymatic DNA through our partnership with Touchlight, our customers will have a critical advantage in terms of scalability and speed to market.”

Touchlight’s dbDNA is a linear, double-stranded, covalently-closed DNA vector. DNA serves as the template for making mRNA therapies. Through a simple enzymatic process called in vitro transcription, genetic information is copied from DNA to mRNA. This mRNA is then able to teach the cells to make precise proteins that are used to treat or prevent diseases. Touchlight’s enzymatic DNA is produced with a cell-free enzymatic process that offers unmatched benefits in speed, quality and capacity when compared to traditional plasmid DNA production.

Karen Fallen, CEO, Touchlight commented: “We are delighted to work with Curia in order to further expand access to dbDNA as a critical starting material. Working in parallel with fellow CDMOs is a key component of our focus upon enabling broad market access to dbDNA. Curia is building a comprehensive mRNA solution, and this arrangement enables both companies to extend their offering to a wider audience.”

Touchlight’s dbDNA is a novel solution that is widely applicable and versatile, advancing Curia’s mRNA manufacturing capabilities as a complement to its bioprocessing-grade plasmid offering.

About Curia

Curia is a leading contract research, development, and manufacturing organization providing products and services from R&D through commercial manufacturing to pharmaceutical and biopharmaceutical customers. Curia’s nearly 4,000 employees at 29 locations across the U.S., Europe, and Asia help its customers advance from curiosity to cure. Learn more at CuriaGlobal.com.

About Touchlight

Touchlight is a privately-owned CDMO based in London, U.K., focused on providing DNA services and manufacturing enzymatically produced doggybone DNA (dbDNA™) to enable the development of genetic medicines. Touchlight provides rapid, enzymatic DNA development and manufacturing for all advanced therapy production, including mRNA, viral and non-viral gene therapy, and DNA API. dbDNA is a minimal, linear, covalently closed structure, which eliminates bacterial sequences. Touchlight’s revolutionary enzymatic production platform enables unprecedented speed, scale, and the ability to target genes with a size and complexity that is impossible with current technologies. Clients can be supported from pre-clinical through development and supply to licensing and tech transfer for use in-house.

Curia Contact Information:
Viana Bhagan
+1 518 512 2111
corporatecommunications@CuriaGlobal.com

Touchlight contact information:

Karen Fallen, Chief Executive Officer
Robin Bodicoat, Head of Marketing
E: info@touchlight.com
T: +44 20 8481 9200

GlobeNewswire Distribution ID 8879177

OPEN Health announces a new team of experts will lead its HEOR & Market Access Scientific Office

London, UK, July 24, 2023 (GLOBE NEWSWIRE) — OPEN Health, a global provider of consultancyHEOR and market access, and scientific communications services, today announced a new team of experts will lead its HEOR & Market Access Scientific Office. This expert team will be led by Dr. Elisabeth Fenwick as Chief Scientific Officer with support from Professor Ben van Hout as Scientific Founder.

Both Elisabeth and Ben joined OPEN Health through its acquisition of Pharmerit International. Elisabeth Fenwick is most widely known for working on the cost-effectiveness acceptability curve (CEAC), creating the cost-effectiveness acceptability frontier, and for her work in value of information analyses for research decisions. She has over 20 years of experience in the industry and has published more than 50 publications globally. Ben van Hout is most commonly known for being one of the co-founders of the EQ-5D (a standardized measure of health-related quality of life) and as the developer of the CEAC. He was also one of the first researchers to perform a discrete event simulation and is published in the New England Journal of Medicine. He has over 35 years of experience in the industry and was honored with the ISPOR Avedis Donabedian Outcomes Research Lifetime Achievement Award in 2020.

“The purpose of the Scientific Office is to ensure that science is at the center of everything we do. Our scientific experts are here to support the HEOR and market access team with their amazing research developing innovative solutions.” Elisabeth commented.

The Scientific Office is made up of experts who bring unique skillsets from across OPEN Health’s HEOR & market access service areas. The appointed team consists of Maarten Treur, MSc, Vice President and Global Head of Modeling & Meta-Analysis; Dr. Viktor Chirikov, Director of Real‑World Evidence & Data Analytics; Dr. Marco Boeri, Director of Preference Research in Patient-Centered Outcomes; and Emanuele Arcà, MSc, Senior Research Consultant in Strategic Market Access. Craig Bennison, MSc, Executive Director and Global Innovation Lead for OPEN Health HEOR & Market Access, will also join the team and will focus specifically on innovation.

“Over the last few years, the scientific contributions and leadership of these experts have played instrumental roles in shaping our reputation and research efforts, working in partnership with our clients to improve health outcomes and patient wellbeing,” said Richard Jones, President of OPEN Health Evidence & Access. “This team will ensure our scientific expertise, thought leadership, and innovation stay front and center of our HEOR and market access offering.”

To learn more about the team of experts in the Scientific Office, please explore this interactive publication.

About OPEN Health

OPEN Health unites deep scientific knowledge with wide-ranging specialist expertise to unlock possibilities that improve health outcomes and patient wellbeing. Working in partnership with our clients, we embrace our different perspectives and strengths to deliver fresh thinking and solutions that make a difference. OPEN Health is a flexible global organization that solves complex healthcare challenges across HEOR and market access, medical communications and creative omnichannel campaigns. For more information on OPEN Health, visit www.openhealthgroup.com.

Candice Subero
OPEN Health
candicesubero@openhealthgroup.com

GlobeNewswire Distribution ID 8878752

Ghana’s former sanitation minister arrested in corruption probe

A former government minister is investigated for corruption in Ghana. The inquiry comes after Cecilia Abena Dapaah reported her housekeeper for stealing a large sum of money, but prosecutors want to know where the money came from. Also in this edition: at least 30 people have been killed by a building collapse in Cameroon. Rescue teams are still on the scene as the government investigates the cause of the disaster. Finally, almost two years after President Kais Saied suspended parliament in Tunisia, rights groups are once again shining a spotlight on the country’s human rights record. We hear from Amnesty International.

Source: France24.com

The Lowdown: The story of a kidney failure patient, Phillip Atawura

In this edition of The Lowdown, Daniel Oduro sits with Phillip Atawura, a GIJ lecturer for an emotional conversation.

The lecturer, who is battling a kidney failure disease, and undergoes dialysis twice a week, revealed that he couldn’t contain his tears when the news of his disease was disclosed to him.

In this episode for The Lowdown, Phillip Atawura walks us through his life and how he deals with the disease as he continues to battle it out.

He further added that he was diagnosed two years ago and pays close to GH¢1,800 for the two sessions of dialysis every week.

Join the conversation with Daniel Oduro on The Lowdown.

Source: Ghana Web

Ghana hikes interest rate to 30%

Ghana’s Central Bank has increased key interest rates 30% to curb the country’s soaring inflation.

This is a 0.5% increase.

The hike was announced on Monday at the end of its monetary policy meeting.

“A hike in rates is the best way to go in the midst of the crisis,” financial analyst Richmond Frimpong told the BBC.

This makes it more expensive to borrow money, and is intended to reduce consumer spending.

The West African nation has been grappling with a battered economy marred by inflation currently over 42%, huge public debts and a cost-of-living crisis.

Last Friday, the World Bank said about 850,000 more Ghanaians were pushed into poverty by the end of 2022 owing to the rising cost of living marred by a loss in purchasing power, and an increase in food prices.

Africa’s largest gold producer has received $600m (£518m), the initial tranche of a $3bn bailout programme from the International Monetary Fund aimed at stabilising its economy while it embarks on debt restructuring and other economic policies aimed at boosting revenues.

Source: BBC

Ghana minister arrested after $1m cash scandal

Ghana’s former Minister for Sanitation and Water Resources Cecilia Dapaah has been arrested by the Office of the Special Prosecutor (OSP) after the reported theft of $1m (£780,000) cash from her house.

According to the OSP, the former minister was placed under house arrest on Sunday 22 July on “suspected corruption and corruption related offenses”.

Many Ghanaians and anti-corruption campaigners have questioned how a public servant could have so much money stashed in their home amid an economic crisis in Ghana.

“Ms Dapaah is being questioned by authorised Officers of the OSP,” the statement read.

Ghana’s President Nana Akufo-Addo accepted her resignation on Saturday following a public outcry.

The money was uncovered after two of her domestic staff were accused of stealing $1m in cash, along with €300,000 and several million Ghana cedis, as well as some personal items.

“I can state emphatically that those figures do not represent correctly what my husband and I reported to the police, I am very much aware of the import of such stories around someone in my position,” Ms Dapaah said.

“I intend to cooperate fully with all state agencies to enable them fully establish the facts,” she added.

Source: BBC

Will China always be the lover Africa can’t do without?

China has undoubtedly become Africa’s trade sweetheart. The love affair between the two often has caused a lot of controversies due to China’s unrivalled dominance in the unceremonious affair between them. Regardless of the opportunities in the relationship, it has always been considered an unmatched affair. Globally, the Africa-China or China Africa trade relationship is a prominent topic for various reasons.

Africa-China trade reached US $282 billion in 2022

China’s exports from Africa are largely raw materials, giving it a net surplus.

Africa imports finished goods from China, resulting in a net deficit yearly.

While Africa is viewed as a vulnerable partner seeking comfort in the loins of her giant lover, China is an undoubted economic celebrity that shoved its way to the top through brass and iron gates and thus has created for itself an image that the world sees as unattractive. It is safe to say China is the lover who is only there for Africa because it wants Africa’s warmth, which comes from abundant natural resources. But what makes this love affair a glorious doom’s creed for Africa, if that is even the case to start with?

Trade volumes have been increasing between China and Africa over the years and, in 2021, reached a record high of $251 billion. However, that was after the figure fluctuated to $176 billion in 2020 due to Covid-19. That singular drop still showed the strong ties between the two trade partners, And if you considered that 20 years earlier, China-Africa bilateral trade only amounted to about $10 billion. This shows that Africa has slowly but steadily walked over and dropped all its trading lines in Chinese pools and is ready to get its fair share of the Chines goodies. The goodies come in many forms, such as generous loans and infrastructure which have become Africa’s biggest lure and bargaining topics in recent years.

There is no denying that Africa’s growing population has given its leaders a dizzying headache for infrastructure, which it clearly cannot meet quickly. That prompted quick and short-term actions out of desperate ion. The activities offered short-term remedies, and their consequences for Africa and benefits are long-term, as exampled by some loan agreements between several countries in the continent with the Asian superpower for infrastructure projects.

Whoever comes to your aid when you are in need is your love, and China is Africa’s love for that simple. China is always ready to give Africa loans that other trade partners cannot or would not give. That made China the de facto influencer of Africa’s decisions and mindset. Chin se businesses in Africa are interested in raw materials and bringing finished goods from Asia, so Africa has conditioned itself to accommodate that need.

Trade boom, China’s win and Africa’s loss

Despite the rising trade volumes between the Asian giant and the desperate but rising African continent, there is room for fear and caution. Trade volumes between n them have surpassed a quarter of a trillion as 2022 trade data showed an 11% increase, with values reaching $282 billion. Africa’s export t China reached $117.51 billion in 2022.

This, if valuable, should have been a significant milestone in Africa’s economic emancipation from external control. However, that cannot be said as most of Africa’s exports are raw materials with crude oil, copper, cobalt, iron ore and natural tobacco. In Sub-saharan Africa, where Chinese trade influence has soared in recent years, replacing French and other Western countries’ trade quotas, as shown in the chart below, about 54% of trade is in raw mate als, according to 2020 trade data.

Worthy of note in this is China’s outspoken commitment to ensuring a trade balance between the two trade partners. In 2018, China’s President Xi Jinping pledged many things to support Africa’s trade growth. Xi pledged that Beijing would promote African brands, offer industrial incentives to Chinese companies to increase their investment in Africa, increase imports from Africa and offer 100,000 scholarships to African students. Additionally, poorer African countries were promised debt exemptions and efforts to make more African products imported to China duty-free were reaffirmed. Following through with that, Beijing announced that beginning December 1 2022, 98% of taxable goods from Benin, Burkina Faso, Guinea-Bissau, Lesotho, Malawi, Sao Tome and Principe, Tanzania, Uganda and Zambia would benefit from the country’s zero-tariff policy, a staggering 8,786 products covered. Also, Beijing’s commitment to Africa’s infrastructure development cannot be underrated though the figures have plummeted since peaking at $11 billion in 2017.

China is not as generous as it claims to be, but it is not as ignoble as perceived by the West. South Africa is the largest bilateral trade partner with China in Africa, and trade volumes between the two countries were over $56 billion in 2022. When you move a year back to 2021, when China exported $20.5 billion to South Africa while importing $20.6 billion back to Asia, the major products were from the extractive industry as gold led with $5.05 billion and diamond at $4.46 billion. This, among other raw material-driven imports of China from Africa, provides China with a trade surplus year in and year out while Africa remains in a trade deficit yearly.

South Africa, as shown in the image above, posted a trade surplus of over $100 million; the same cannot be said of Nigeria, where China earned a net surplus of over $17 billion after exporting $21.9 billion to the Western African country while only importing $3.05 billion nearly half of which was petroleum gas. Angola, another of China’s major trade partners in Africa, achieved $18.12 billion in 2021 and, by May of 2022, already had a surplus of $1.3 billion over China in trade. But considering that most of those are in natural gas and petroleum products such as crude speaks volumes of how Africa is still a minor in this over two-decades-long trade romance.

Why Africa-China is going nowhere soon

Despite the advantage of China in exporting finished goods to Africa and importing raw materials which are low valued in return, China will remain Africa’s long-term sweetheart for various reasons.

China’s economic growth: the United States undoubtedly remains the owner of the title of a global super economy, but that is now more like a team that describes a group that includes China than a term referring to one nation. China has become the most important threat to the USA’s global economic control and ranks second globally, with a gross domestic product (GDP) of $17.825.5 billion. That is about $5 billion less than the United States $23,325.1 billion in 2021. With that growth is the rising need for raw materials to feed its huge manufacturing industry, which has kept China looking outside its borders for relief and that places its paths direct to Africa.

Africa’s natural resources: just like the first reason for China’s continued bonding with Africa, the continent also has more even to attract the Chinese. Nearly all of Africa’s 54 countries and territories have something of value to China. From crude to minerals all the way to agriculture, the continent has all that China needs.

So with a need to satisfy and another with the resources that it largely cannot turn into something significant, China would do everything to remain around for a very long time until Africa begins to add value to its natural resources by turning them into finished products. If that is done and the cost of the products rises, China may consider other options outside the continent and only then will the affair be threatened. If you follow the trend, though has been instances of trade volume decline between the two regions, it has always risen and performed even better, as shown in the chart below.

Africa’s growing population: Africa is the youngest continent globally and has a population of over a billion. This creates a very large market that is hungry and waiting to be satisfied. China has a large manufacturing industry that can produce goods very cheaply. That makes the two regions attractive as Africa provides the market and China the goods to satisfy the market. This can be concluded to be a win-win scenario for both parties. Still, economically and based on attaining sufficiency, Africa is losing out by serving as the market for finished products from China. In the short term, Africa cannot meet its growing population’s needs for clothing, electronic appliances, and other consumable goods. Hence, China remains the convenient lover as other options are comparably expensive.

Belt and road initiative: arguably China’s largest attempt to stamp its influence globally, the Belt and Road Initiative (BRI) has been oversubscribed by Africa, particularly due to the promise of development. Africa’s greatest need now, besides good leadership, is infrastructure, so it is desperate to enter into any relationship that offers that. To tell how Africa is desperate to have these projects under BRI, 44 African countries have joined BRI. So if anyone thought China and Africa would be gone soon, that needs rethinking because the signs all point to a long future together.

China’s “Go Out” policy: China implemented the “Going Out” policy in 2000 to encourage Chinese companies to invest outside the country. That move saw China surge in global influence as it became the second largest country with foreign direct investment (FDI) outflow behind the United States. In 2012, China’s FDI outflow reached a staggering $84.2 billion, up from $2.7 billion ten years before. Ten years later, in 2022, China accounted for a $150 billion FDI outflow globally.

It was only bettered by Japan in second place with $162 billion and the United States in first with $403 billion, according to a report by OECD. That policy has also been the driving force behind the increasing amount of loans and credit facilities offered by China to Africa. Nearly all the countries have some sort of a loan from China.

The above reasons, among others, have kept Africa and China together in the first place. And would keep them together long into the future.

Regardless of whether the relationship between Africa and China is far from a win-win affair, it is undeniable that Africa has been a bigger beneficiary of China’s outstretched arm of generosity. There cannot, not be a price to pay for every free gift received. So China definitely is expected to get its returns for being generous to Africa, but the ball is in Africa’s court to decide what is good for its people and do what is necessary to get that.

China cannot be Africa’s economic foe but a great ally if only Africa decided right and acted right to take the opportunities presented by China’s desperate need for resources. This can be done by African leaders shifting the negotiation from China exporting raw materials from the continent to the country supporting Africa to add value to the products that China needs in Africa.

Metals are needed for China’s construction and manufacturing industry, so instead of exporting raw ore, they could be turned into ready-made material for onward export to feed the Chinese industry. Crude and other major resources exported from Africa to China can be refined before lifting them out.

Until then, Africa and China’s love affair would continue to be seen as an uneven patch of romance based on lack and need.

Source: Ghana Web

You kill me everyday, you want me to talk to you guys! – Sadio Mane hits German media

‘You’re killing me everyday, now you want me to talk to you guys’ – Sadio Mane calls out German press

Senegalese international Sadio Mane has expressed his dissatisfaction with the German press, claiming that they are killing him everyday.

Despite having a bright start to life at Allainz Arena, the former Liverpool man fell on hard times in his first season after a dressing room altercation with a team mate.

He has since been declared surplus to requirement according to some reports for the coming season.

In a video posted on social media, the player on his way to training obliges a fan for a photograph but changes his countenance when a pressman approached with his cameraman in tow.

“You are killing me everyday and now you want me to talk to you guys! Come on.” he said as he walks away.

Source: Ghana Web