Taconic Biosciences Launches First and Only Super Immunodeficient Mouse Models Lacking Residual Murine Fc Gamma Receptors, for Improved Antibody Therapy Assessment

FcResolv™ NOG Models Provide Greater Clarity and More Translatable Data

RENSSELAER, N.Y., Oct. 24, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, has launched the FcResolv™ NOG portfolio, the first and only super immunodeficient mouse models lacking residual murine Fc gamma receptors (FcγRs) known to confound results in antibody-based therapy studies.

Murine FcγRs can cause false positives or false negatives, leading to incorrect conclusions and derail drug discovery. FcResolv NOG models knock out these receptors for greater clarity in antibody-based drug studies, affording investigators greater confidence and more translatable data with fewer studies and fewer animals. With applicability in oncology, immuno-oncology, and autoimmune disease, FcResolv NOG models are suitable for engrafting a wide range of human cells and tissues, including simultaneous human tumor engraftment and immune system humanization.

“Antibody-based therapies represent one of the fastest-growing classes of drugs, creating a pressing need for better preclinical tools to assess therapeutics such as monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “Taconic’s FcResolv NOG portfolio enables researchers to evaluate drug candidates like these on their own merits, free of interference from residual murine Fc gamma receptor activity.”

FcResolv NOG models eliminate the false negatives that occur when an antibody-based therapeutic’s Fc domain interacts with murine FcγRs as well as the false positives that result when FcγRs trigger residual murine immune activity. They also eliminate costly deconvolution steps otherwise needed to distinguish true drug efficacy from off-target effects mediated through the mouse immune system. With more reliable answers, researchers can target their drug discovery investments more strategically and effectively.

The FcResolv NOG model portfolio is based on the super immunodeficient CIEA NOG mouse®. The portfolio currently includes two models:

  • FcResolv NOG, for tumor xenografts using cell lines or patient-derived tumors, engraftment of other normal or pathological human cells and tissues, and immune system humanization studies
  • FcResolv hIL-15 NOG, which supports engraftment of human NK cells and is suitable for efficacy studies on antibody-based therapeutics with an antibody-dependent cellular cytotoxicity (ADCC) mechanism of action

To learn more about the FcResolv NOG portfolio, visit www.Taconic.com/fcresolv. Or call 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates service laboratories and breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Louise Baskin, Senior Director New Product Pipeline

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670208

Taconic Biosciences lance le premier et le seul modèle de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels, pour une évaluation améliorée de la thérapie par anticorps

Les modèles FcResolv™ NOG offrent une plus grande clarté et des données plus traduisibles

RENSSELAER, New York, 24 oct. 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, un leader mondial dans la fourniture de solutions de modèles animaux pour la découverte de médicaments, a lancé le portefeuille FcResolv™ NOG, les premiers et seuls modèles de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels (FcyRs) connus pour fausser les résultats dans les études thérapeutiques à base d’anticorps.

Les FcyRs murins peuvent provoquer de faux positifs ou de faux négatifs, ce qui conduit à des conclusions erronées et fait dérailler la découverte de médicaments. Les modèles FcResolv NOG éliminent ces récepteurs pour une plus grande clarté dans les études médicamenteuses à base d’anticorps, offrant aux chercheurs une plus grande confiance et des données plus traduisibles avec moins d’études et moins d’animaux. Avec une applicabilité en oncologie, en immuno-oncologie et en maladie auto-immune, les modèles FcResolv NOG sont adaptés à la greffe d’un large éventail de cellules et tissus humains, y compris la greffe de tumeurs humaines simultanée et l’humanisation du système immunitaire.

« Les thérapies à base d’anticorps représentent l’une des classes de médicaments à la croissance la plus rapide, créant un besoin urgent de meilleurs outils précliniques pour évaluer des traitements tels que les anticorps monoclonaux, les conjugués anticorps-médicaments et les anticorps bispécifiques », a déclaré le Dr Michael Seiler, vice-président des produits commerciaux chez Taconic. « Le portefeuille de récepteurs FcResolv NOG de Taconic permet aux chercheurs d’évaluer des médicaments candidats tels que ceux-ci selon leurs propres mérites, sans interférence de l’activité résiduelle du récepteur Fc Gamma murin. »

Les modèles FcResolv NOG éliminent les faux négatifs qui se produisent lorsqu’un domaine Fc thérapeutique à base d’anticorps interagit avec les FcyRs murins, ainsi que les faux positifs qui en résultent lorsque les FcyRs déclenchent une activité immunitaire murine résiduelle. Ils éliminent également les étapes de déconvolution coûteuses nécessaires pour distinguer une véritable efficacité médicamenteuse des effets hors cible induits par le système immunitaire de la souris. Grâce à des réponses plus fiables, les chercheurs peuvent cibler leurs investissements dans la découverte de médicaments de manière plus stratégique et plus efficace.

Le portefeuille de modèles NOG FcResolv est basé sur la souris® NOG CIEA super immunodéficiente. Le portefeuille comprend actuellement deux modèles :

  • FcResolv NOG, pour les xérogreffes tumorales utilisant des lignées cellulaires ou des tumeurs dérivées des patients, la greffe d’autres cellules et tissus humains normaux ou pathologiques, et les études d’humanisation du système immunitaire
  • FcResolv hIL-15 NOG, qui supporte la greffe des cellules NK humaines et convient pour des études d’efficacité sur les thérapies à base d’anticorps avec un mécanisme d’action de cytotoxicité cellulaire dépendant des anticorps (ADCC)

Pour en savoir plus sur le portefeuille de FcResolv NOG, rendez-vous sur www.Taconic.com/fcresolv. Vous pouvez également appeler le 1-888-TACONIC (888-822-6642) aux États-Unis, le +45 70 23 04 05 en Europe, ou envoyer un e-mail à l’adresse info@taconic.com.

À propos de Taconic Biosciences, Inc.

Taconic Biosciences est un leader mondial pleinement agréé dans les modèles et les services de rongeurs génétiquement modifiés. Fondée en 1952, Taconic offre les meilleures solutions animales afin que les clients puissent acquérir, générer d’une manière personnalisée, élever, pré-conditionner, tester et distribuer des modèles de recherche précieux dans le monde entier. Spécialiste des modèles de souris et de rats génétiquement modifiés, du microbiome, des modèles de souris pour l’immuno-oncologie et des services de conception de modèles intégrés et d’élevage, Taconic exploite des laboratoires de services et des établissements d’élevage aux États-Unis et en Europe, entretient des relations de distribution en Asie et dispose de capacités d’expédition mondiales pour fournir des modèles animaux presque partout dans le monde.

Contact auprès des médias :

Louise Baskin, directrice principale du nouveau Pipeline de produits

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426


Taconic Biosciences Lança Primeiro e Único Modelo de Camundongo Super Imunodeficiente Sem Receptores Gama Fc Murino Residuais, para Avaliação de Terapia de Anticorpo Aprimorada

Modelos FcResolv™ NOG proporcionam dados mais claros e mais traduzíveis

RENSSELAER, NY, Oct. 24, 2022 (GLOBE NEWSWIRE) — A Taconic Biosciences, líder global no fornecimento de soluções de modelo animal para descoberta de medicamentos, lançou o portfólio FcResolv™ NOG, o primeiro e único modelo de camundongo superimunodeficiente sem receptores Fc gama murinos residuais (FcγRs) conhecidos por confundir os resultados nos estudos de terapia com base em anticorpos.

Os FcγRs murinos podem causar falsos positivos ou falsos negativos, levando a conclusões incorretas e afetar a descoberta de medicamentos. Os modelos FcResolv NOG eliminam esses receptores para maior clareza nos estudos de medicamentos com base em anticorpos, proporcionando aos investigadores maior confiança e dados mais traduzíveis, com menos estudos e menos animais. Com aplicabilidade em oncologia, imuno-oncologia e doença autoimune, os modelos FcResolv NOG são adequados para enxertos de uma ampla gama de células e tecidos humanos, incluindo enxerto simultâneo de tumor humano e humanização do sistema imunológico.

“As terapias com base em anticorpos são uma das classes de medicamentos de crescimento mais rápido, criando uma necessidade urgente de melhores ferramentas pré-clínicas para a avaliação terapêutica, como de anticorpos monoclonais, conjugados anticorpo-droga e anticorpos biespecíficos”, disse o Dr. Michael Seiler, vice-presidente de produtos comerciais da Taconic. “O portfólio FcResolv NOG da Taconic permite que pesquisadores avaliem candidatos a medicamentos como esses por si próprios, sem interferência da atividade residual do receptor Fc gama murino.”

Os modelos FcResolv NOG eliminam os falsos negativos que ocorrem quando o domínio Fc de um terapêutico com base em anticorpos interage com os FcγRs murinos, bem como os falsos positivos que resultam quando os FcγRs desencadeiam atividade imune murina residual. Eles também eliminam as etapas dispendiosas de desconvolução que normalmente são necessárias para distinguir a verdadeira eficácia do medicamento dos efeitos fora do alvo mediados pelo sistema imunológico do camundongo. Com respostas mais confiáveis, os pesquisadores podem direcionar seus investimentos em descoberta de medicamentos de forma mais estratégica e eficaz.

O portfólio do modelo FcResolv NOG tem como base o CIEA NOG mouse® superimunodeficiente. Atualmente, o portfólio inclui dois modelos:

  • FcResolv NOG, para xenoenxertos de tumores com linhagens celulares ou tumores derivados de pacientes, enxerto de outras células e tecidos humanos normais ou patológicos, e estudos de humanização do sistema imunológico
  • FcResolv hIL-15 NOG, que aceita enxertos de células NK humanas e é adequado para estudos de eficácia em terapêutica com base em anticorpos com um mecanismo de ação de citotoxicidade celular dependente de anticorpos (ADCC)

Para mais informação sobre o portfólio FcResolv NOG, visite www.Taconic.com/fcresolv. Ou ligue para 1-888-TACONIC (888-822-6642) nos EUA, +45 70 23 04 05 na Europa, ou envie email para info@taconic.com.

Sobre a Taconic Biosciences, Inc.

A Taconic Biosciences é uma líder global totalmente licenciada em serviços e modelos geneticamente modificados. Fundada em 1952, a Taconic oferece as melhores soluções/modelos de pesquisas em murinos, para que os clientes possam adquirir, customizar, criar, pré-condicionar, testar e distribuir valiosos modelos de pesquisa em todo o mundo. Especializada em modelos de camundongos e de ratos geneticamente projetados, microbioma, modelos de camundongos imuno-oncologia, e serviços de design e criação de modelos integrados, a Taconic opera laboratórios de serviços e instalações de criação nos EUA e na Europa, mantém relações com distribuidores na Ásia , e tem capacidades de entrega em nível global para oferecer modelos em quase qualquer lugar no mundo.

Contato com a Mídia:

Louise Baskin, Diretora Sênior de Pipeline de Novos Produtos

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426

Nkwanta North NDC gets new executives

Dambai (O/R) Oct. 24, GNA – Mr Isaiah Kudjoe Dordoe has been elected as the Constituency Chairman of the National Democratic Congress (NDC) in the Nkwanta North of the Oti region.

Mr Dordoe, who polled 538 votes, told the Ghana News Agency (GNA), he would not relent in his efforts in putting the party together in the Constituency ahead of the 2024 election.

He strongly appealed to the newly elected executives to remain united and focus on the greater task ahead of them.

Other elected executives are Mr Yagban Olu, Vice Chairman, Mr Samuel Kofi Kilifingh, Secretary and Mr Thomas Dawuni Ntakpayor, Deputy Secretary.

Mr Geyam Kwame was voted as the Organizer, Mr Ndombe Kolon, Deputy Organizer, Madam Sara Aja Gbande, Women Organizer and Madam Udatu Abdul Karim as Deputy Women Organizer.

The position of Youth Organizer went to Mr Joshua Kunjin while Mr Wayo Bajimpoan got the nod as Deputy Youth Organizer.

Other Youth Organizer went Mr Abdulai Hamza, the Treasurer elect is Mr Tahiru Yakubu and Mr Edward Niliyung Belabame as Deputy Treasurer.

Mr David Nalibey Umborkan was elected as Communication Officer, Mr Gideon Bilinyi as Deputy Communication Officer and Mr Abubakar Alhassan as Zongo Caucus Coordinator.

The other eight executive members are Mr David Nponpir, Mr Rashid Yussif Zakari, Mr Adams Ali Champua, Mr Silas Tinanyun, Madam Beatrice Mensah, Mr Osman Abubakar, Mr Azizu Maifetorm and Mr Tibornyan Yajabrum.

 

 

Source: Ghana News Agency

Ho Central re-elects Gedzia as NDC Chairman

Ho, Oct. 24, GNA – Delegates of the National Democratic Congress (NDC) in the Ho Central Constituency have reelected Franklyn Gedzia as Chairman.

The businessman beat his sole opponent, fellow businessman Gershon Adeklo.

He said the victory belonged to all in the Party and rallied supporters for the ultimate victory at the 2024 general elections.

“You are prepared for war. We are ready for war and this war is not going to be with the gun. Victory for 2024 has just begun and we all should be prepared for the battle. We will unite and sack the elephant into the sea at Keta.

“Come together. If you have anything to offer, come and join us,” Mr. Gedzia stated.

Kofi Homado, former Minister, who swore them in, commended the comportment throughout the exercise.

“I am delighted and happy, and my report to the regional executives will be a very good one”.

The Electoral Commission had adopted a multiple collation system to speed up the exercise, which includes 17 positions and more than 50 contestants.

More than 2,200 delegates were involved, and polling centres were multiplied to aid speed.

Divine Ferg Afedo, Elections Committee Chairman for the exercise, told the Ghana News Agency (GNA) that the strategy had worked well for the constituency, which was among the largest in the country.

He said the exercises had not been with minor challenges, yet “generally peaceful, fair and free”, and commended all.

Presiding Member of the Ho Municipal Assembly, Mawunyo Agbe, was retained Vice Chairman with 1449 of votes cast.

Margaret Akua Dzogbewu was elected Women Organizer with 56 per cent of votes.

Cyril Fiator beat former Municipal Chief Executive Isaac Kojobisah and two others to the secretary position.

Alhaji Muhamed and Agama Sefadzi were retained as Organizer and Communications director respectfully.

Vincent Ameko, was elected treasurer, and Matala Hamza won Zongo Caucus Coordinator with 54.5 per cent votes.

Twelve executive members were also elected.

The new Women Organiser, a teacher at the Awudome Senior High School, was grateful for the opportunity, and told GNA she was “looking at skills training and employment for women and youth”.

Mrs. Dzogbewu said she would use just the mantle to lead the campaign for a review of the free SHS programme.

 

 

Source: Ghana News Agency

Opoku Da-Rocha elected NDC constituency chairman for Asante Bekwai

 

Asante Bekwai (Ash), Oct. 24, GNA – The Asante Bekwai constituency of the National Democratic Congress (NDC) on Sunday elected Mr Opoku Da-Rocha, as the new constituency chairman.

Mr Da-Rocha polled 556 votes to beat three other contestants, including the incumbent, Mr Collins Sarkodie, who had 330 votes.

The first Vice Chairman position went to Mr Charles Oppong, who had 570 votes, while Mr Hussain Kada Tidjani, the incumbent secretary, retained his position with 847 votes.

Other executive members elected during the peaceful elections were Mr Ayuba Alhassan, Deputy Secretary, Mr Salifu Baba, Organizer, Abdul Rauph Abubakar, Youth Organizer, Ms. Abiba Yakubu, Women’s Orgnizer, Mr Edward Adarkwah Treasurer and Mr Gabriel Asiedu, Communication Officer.

Mr Da-Rocha speaking after the elections, thanked the delegates for the confidence repose in him.

He said the peace and unity exhibited during the elections was a clear demonstration that the party was united and stronger to wrestle power in the 2024 general elections.

Mr Da-Rocha called on all the party members to come together and work hard to win the seat for the NDC in the 2024 elections.

Source: Ghana News Agency

Parliament reconvenes tomorrow for third meeting

Accra, Oct 24, GNA – The Third Meeting of the Second Session of the Eighth Parliament of the Fourth Republic reconvenes tomorrow, Tuesday, October 25, 2022.

A statement issued by the Office of the Speaker of Parliament, Mr Alban Bagbin, and copied to the Ghana News Agency, has said.

It said: “In pursuance of Standing Order 37 of the Parliament of Ghana, I, Alban Sumana Kingsford Bagbin, Speaker of Parliament, hereby give notice that the Third Meeting of the Second Session of the Eighth Parliament of the Fourth Republic shall commence on Tuesday, the 25th day of October 2022, at ten o’clock in the forenoon at Parliament House, Accra.”

In a related development, a statement from the Public Affairs Directorate of Parliament, Monday, said Sixty-six Bills, including the Affirmation Action Bill, 2022, Ghana Housing Authority Bill, 2022, Minerals and Mining (Amendment), 2022, Small Scale Mining Bill, 2022, Petroleum Revenue Management (Amendment Bill, 2022 and the Constitution of the Republic of Ghana (Amendment) Bill, 2021 were expected to be laid before the House.

It said a Private Members Bill, which was referred to the Council of State would also be laid before the House.

Eleven Bills are currently at the committee level, out of which seven are Public Bills and four, Private Members bills.

Among them are the Intestate Succession Bill, 2022, at the Committee on Constitutional, Legal and Parliamentary Affairs, the Armed Forces (Amendment) Bill, 2022, at the Committee on Defence and Interior, the Promotion of Proper Human Sexual Rights and the Ghanaian Family Values Bill, 2021, at the Committee on Constitutional, Legal and Parliamentary Affairs and the Criminal Offences (Amendment) Bill, 2021, at the Committee on Constitutional, Legal and Parliamentary Affairs.

According to the statement, there were also Instruments at various stages to be laid before the House.

“The Speaker is expected to admit Papers, Petitions, Motions for Debates and Questions to be answered by sector ministers during this meeting,” it said.

Other events during the meeting will be the presentation of the annual budget for 2023 and the festival of nine lessons and carols.

The House adjourned sine-dine on Thursday, July 28, 2022.

“Mr Speaker, barring any unforeseen circumstances, the Hosue is expected to resume the third week in October,” Mr Osei-Kyei Mensah-Bonsu, Majority Leader said.

Members of Parliament (MPs) go into recess thrice in a Session – the first recess is from March to May, the second, from July to October with the last being December to January.

The MPs use the recess for committee meetings, visiting their constituencies and other Parliamentary-related works.

 

Source: Ghana News Agency

Afriyie Barnieh scores twice to give Ghana win over Mozambique in CAF U-23 Africa qualifiers 

 

Accra, Oct. 24, GNA – Accra Hearts of Oak’s forward Afriyie Barnieh scored twice to give Ghana an important win over Mozambique in the CAF U-23 Africa Championship qualifiers played at the Estadio do Zimpeto, Maputo.

The match ended 1-2 in favour of the Black Meteors of Ghana.

Barnieh scored from the spot in the 61st and 76th minute before the hosts pulled one back in the dying minutes of the match.

The impressive performance from Coach Ibrahim Tanko’s charges give Ghana an advantage as they welcome Mozambique on Sunday, October 30 at the Baba Yara Sports Stadium for the return encounter.

A win for Ghana at home will see the Black Meteors cruise to the last round of the qualifiers to meet either Ethiopia or Algeria for a slot in the final competition.

The team is expected to return on Tuesday, October 25, to continue preparations in Kumasi ahead of the fixture.

 

Source: Ghana News Agency