Taconic Biosciences Adds New Humanized Immune System (HIS) Model to Its Portfolio For Immuno-Oncology Research

New huNOG-EXL EA Model Extends Study Windows Significantly

RENSSELAER, N.Y., Jan. 18, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of the huNOG-EXL EA (Early Access) humanized immune system (HIS) mouse. This product expands Taconic’s widely used HIS portfolio. huNOG-EXL EA significantly lengthens the study window during which a myeloid-lineage HIS mouse model can be used successfully.

Taconic’s huNOG-EXL models support human myeloid and lymphoid cells, making these mice especially useful for immuno-oncology research and other immune-related applications. With the longest lifespan of any myeloid-supportive HIS model, the original huNOG-EXL model (now called huNOG-EXL SA, or Standard Access) has been successfully applied in preclinical drug discovery research since 2016. The huNOG-EXL SA model is provided after a quality control step at 10 weeks post-engraftment. Feedback from users suggests research applications requiring particularly long study timelines or importation into regions with long quarantine periods present experimental and logistical hurdles that can limit the utility of the Standard Access (SA) model.

The new huNOG-EXL EA model removes those challenges by providing access to huNOG-EXL mice soon after engraftment, extending the useful study window. This makes the huNOG-EXL EA ideal for engraftment of slow-growing tumors, longer treatment paradigms, or various study customizations. Early access to an extended myeloid lineage model is also advantageous to researchers who face model importation quarantines, which would otherwise consume a significant portion of the useful study window for these mice. Because the huNOG-EXL EA model is shipped before an engraftment QC step is possible, it is made using cells from donors previously validated to engraft well so as to reduce the risk of engraftment failures.

“The huNOG-EXL EA model meets critical scientific needs for investigators performing immuno-oncology research or studying other immune-related diseases,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “After conducting extensive research and development, along with rigorous beta testing with several industry partners, Taconic is excited to now offer the new model and expand the usefulness of this unique humanized mouse.”

To learn more about Taconic’s huNOG-EXL EA model, please contact us at 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates three service laboratories and six breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Nancy J Sandy




OKX overtakes global crypto exchanges as 2nd largest, rebrands as cross-platform services provider

Formerly OKEx, OKX’s new brand highlights the platform’s robust suite of crypto, NFT and DeFi investing products

VICTORIA, Seychelles, Jan. 18, 2022 (GLOBE NEWSWIRE) — OKX, which recently became the second largest cryptocurrency exchange in the world by spot trading volume, today announced a company-wide rebrand that reflects the dynamism and accelerating adoption of cryptocurrency. Founded in 2017 as a cryptocurrency trading service, OKX has since amassed over 20 million users and expanded its suite of digital asset investing products to include OKX Earn, a tool for earning passive crypto income; an NFT marketplace and decentralized application discovery hub; and most recently, MetaX, OKX’s new decentralized mode that features a cross-chain dashboard and self-custody Web 3.0 wallet for storing digital assets, including NFTs.

This shift, as highlighted by the company’s name change from OKEx to OKX, reflects the platform’s growing number of wealth creation opportunities beyond the exchange, which investors use to trade hundreds of digital assets on spot, margin and derivatives markets.

As part of the move, OKX has declared its mission to be “to remove barriers to wealth creation by giving you access to everything our decentralized future holds.” This underscores the platform’s ongoing evolution towards decentralization, which includes giving investors the option to self-custody their digital assets. Distinct from other centralized cryptocurrency exchanges, OKX is committed to gradually decreasing the company’s level of involvement in user activity, with the ultimate goal of shedding intermediation entirely.

“OKX is moving beyond the standard centralized exchange model to give our customers an end-to-end cryptocurrency experience,” said Jay Hao, CEO of OKX. “Most importantly, we’re doing this while upholding the core principles of crypto — decentralization and autonomy. Our goal is to give customers the tools they need to easily and securely earn, transfer, and spend their wealth as they see fit, without intermediation from us. We’ve dropped the ‘E’ from our name because we’re so much more than an exchange, just like crypto is so much more than a speculative asset.”

OKX, which lists over 250 digital assets and has long held the #1 rank for cryptocurrency futures trading volumes, recently became the second largest cryptocurrency spot trading platform in the world. In 2021, total trading volume on the platform, including spot and derivatives instruments, grew over 700%, while the number of trades executed on the platform increased over 480%. Staking, savings and DeFi offerings via OKX Earn saw over $5.1 billion deposited by users, and paid out over $314 million in passive income this past year.

To learn more, please visit OKX.com and follow @OKX on Twitter.

About OKX

Founded in 2017, OKX is a world leading cryptocurrency exchange and ecosystem. OKX has innovatively adopted blockchain technology to reshape the financial ecosystem and offers some of the most diverse and sophisticated products, solutions and trading tools on the market. Trusted by more than 20 million people in 180 regions across the globe, OKX’s mission is to remove barriers to wealth creation by offering access to everything the decentralized future holds. With its unwavering commitment to innovation, OKX envisions a world of financial inclusion for all through the power of crypto and decentralized finance.

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Email: media@okx.com
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Good news for kung fu enthusiasts around the world – Shaolin Temple launches kung fu online games

DENGFENG, China, Jan. 18, 2022 /PRNewswire/ — With the Chinese New Year around the corner, China’s Songshan Shaolin Temple and Shaolin Culture Centers across the world have launched a global kung fu contest – “Happy Chinese New Year: Shaolin Kung Fu Online Games.”

“Shaolin kung fu boasts the value of fitness, enlightenment, and harmony,” said the abbot of the Shaolin Temple, Master Shi Yongxin. “As countries around the world battle the COVID-19 pandemic, the Shaolin Temple launched the competition online with the aspiration of promoting peace, friendship, and health, hoping that kung fu fans around the globe gain health, fitness, and happiness,” the abbot added.

The Shaolin Temple organizes year-end kung fu examinations for the monks at the end of each year to encourage kung fu monks to be more brave and diligent.

This year, the examination will be launched online for kung fu lovers of all ages across the globe. Participants will only need to upload a video to the official website of the activity.

The online kung fu games promote communication and interaction between people around the globe against the backdrop of epidemic curbing. The online games are not only an arena for global competitors but also a joyous “family reunion” of all kung fu enthusiasts.

The Chinese zodiac sign of 2022 is the Tiger, and the tiger represents justice, majesty, bravery, and diligence in Chinese culture, which identifies with the concept of Shaolin kung fu.

Shaolin Kung fu has a long history of more than 1,500 years and is one of China’s top-level martial art schools with a complete system. As a national intangible cultural heritage of China, Shaolin kung fu illustrates the desire for supernatural powers and the pursuit of extraordinary wisdom.

The Shaolin Temple has established Shaolin Culture Centers in more than 120 cities on five continents, with more than tens of millions of disciples. Former South African President Nelson Mandela praised Shaolin culture for the human values it instills. Moreover, Stephen Orlins, president of the National Committee on United States-China Relations recalled the legacy of the “ping-pong diplomacy” when talking about Shaolin kung fu, after watching a kung fu performance at the United Nations headquarters.

Registration for the games is now open until January 20 at 24:00, local time. Please visit the official website and App of the Shaolin Temple for more details.

Photo – https://mma.prnewswire.com/media/1728275/image_1.jpg

Hearts of Oak suspend captain Fatawu Mohammed for two weeks

Accra Hearts of Oak have announced that Fatawu Mohammed, who is the captain of the side has been suspended for two weeks for violating the terms of his contract.

The Ghana Premier League champions announced the decision via their social media handles on Tuesday afternoon.

The club in a statement said, during the period of the suspension, Fatawu will be required to train with the junior team.

In his absence, Mohammed Alhassan will act as captain.

Mohammed was absent during Sunday’s 4-1 win over Eleven Wonders at the Accra Sports Stadium.

During the period of his suspension, the 29-year old will be required to train with the junior team.

The club announced Mohammed Alhassan will act as captain in his absence.

Source: Modern Ghana

Long queues continue to mark SIM re-registration exercise

Accra,- Long queues continue to mark the SIM re-registration exercise despite measures put in place by authorities to ease congestions at the various centres.

The National Communications Authority (NCA) early this month indicated that it was in talks with the various Mobile Network Operators (MNOs) to mitigate the challenges that had charactised the process in the early stages.

“The Ministry of Communication and Digitisation (MoCD) and the NCA are working collaboratively with the MNOs to ensure that the SIM registration process is enhanced to make it fast, secure, safe and convenient for customers,” a statement issued by the Authority, said.

Some Mobile Network Operators such as MTN, had earlier also indicated that it had put in place measures to curb the long queues, particularly at its offices.

However, checks by the Ghana News Agency at some SIM registration centres at Dansoman, in the Ablekuma West Municipality of the Greater Accra Region, revealed that nothing significant had changed regarding the queues, as well as the pace of the registration process.

Apart from the Vodafone Office, which had few customers who were being attended to by the time GNA arrived at 0950 hours, long queues persisted at the AirtelTigo and MTN offices in the area, as subscribers waited anxiously for their turn to register.

In an interview with the GNA, Mohammed Iddrisu, MTN subscriber, said the exercise was extremely tedious and time wasting.

Mr Iddrisu said, on three occasions, he had failed to have his SIM registration due to the long queues he often met at the centre.

“With advancement in technology, we should not be hustling to have a SIM card registered this way,” he decried.

Berlinda Asamoah, an AirtelTigo subscriber, reiterated the need for Government to reconsider the deadline for the exercise and extend it to ease the current burden on both subscribers and the telcos.

She also appealed to the relevant authorities to introduce swifter measures to help ease the congestions and make the process faster.

The SIM registration exercise, which commenced on October 1, 2021, is officially expected to end on March 31, 2022.

The exercise, has however, been plagued with many challenges early this year, including long queues at registration centres and slow pace of the registration process.

Many Ghanaians have, therefore, called on the Government to extend the deadline.

It is in accordance with the Subscriber Identity Module Registration Regulations, 2011, LI 2006 to, among other objectives curb SIM boxing and other criminal activities.

According to the directive from the Ministry of Communication and Digitisation, any SIM card that is not accordingly re-registered with biometric information will be blocked.

Source: Ghana News Agency

George Padmore Library to charge tourists

Accra, – The George Padmore Research Library will soon start charging tourists who visit and patronise the facility.

Mr Simon Teye, Director at the Library, told the Ghana News Agency that Management had had discussions with the Executive Director of Ghana Library Authority on the necessary steps to raise some revenue.

“Originally, we are not mandated to charge for services rendered to tourists, who visit the facility unlike the Du Bois Memorial Center and Kwame Nkrumah Memorial Park,” but

“ashes of the late Pan-Africanist have been interred at the facility and this is attracting tourists so we need something maintain the place…”

“We will charge and will do so within the law,” he added.

Mr Teye said the COVID-19 pandemic had impacted negatively on the number of people who visited the facility for both tourism and research purposes in 2020 and mildly in 2021.

He explained that in 2021, the facility recorded 5,600 visits to the Library compared to to 15,000 in 2017 and 2018.

Out of the number, close to 70 tourists, all foreign nationals, some being Africans from the diaspora, visited the facility in 2021.

The George Padmore Research Library is a monument established by Ghana’s First President, Dr Kwame Nkrumah,in his honour on June 30, 1961 and located at Ring Way, Osu in Accra.

The Pan-Africanist, who was named after the facility, was born on June 28, 1903, in Trinidad in the Caribbean.

He was a journalist and an author.

From 1945, Kwame Nkrumah developed close relations with Mr Padmore during the Organisation of the fifth Pan-African Congress held in Manchester, United Kingdom on October 1945.

Upon his arrival in Ghana in 1957, he (Kwame Nkrumah) set up an office, which focused on African Liberation.

It was after the death of Mr Padmore in 1959 that Dr Nkrumah built the George Padmore Research Library of African Affairs as a monument in his honour.

He authored over 50 books, including the popular “Pan-Africanism or Communism.”

Source: Ghana News Agency

Guinea through to next round despite defeat to Zimbabwe

Guinea reached the last 16 at the Africa Cup of Nations despite losing their final Group B match 2-1 against already-eliminated Zimbabwe.

Knowledge Musona’s downward header and Kudakwashe Mahachi’s low strike put the Warriors two up at half-time.

Guinea captain Naby Keita replied with a stunning goal in Yaounde, in a match which saw referee Salima Mukansanga make history.

The Rwandan, 35, became the first woman to referee a Nations Cup game.

Guinea finish second in the group table, ahead of Malawi on head-to-head record after the Flames drew 0-0 with Senegal.

The West Africans will now face the runners-up from Group F on Monday, 24 January but will be without Liverpool midfielder Keita, who will be suspended after picking up his second booking at the tournament.

The opening goal came in the 26th minute when Guinea could only half-clear a corner that Never Tigere curled invitingly back into the danger zone for the unmarked Musona to glance home.

Mukansanga’s first real involvement came when she brandished her first yellow card, booking Ibrahima Cisse for a raised elbow.

Zimbabwe were able to take advantage of their lethargic opponents two minutes before the break when Syli National failed to react to a quickly taken free-kick, the move eventually resulting in a low drive from Mahachi that should have been saved but instead squirmed under the body of Aly Keita.

Coached by former Arsenal forward Kaba Diawara and cheered on by several groups of noisy supporters, Guinea improved after half-time.

Skipper Keita produced the game’s one moment of true class in the 49th minute, cutting in from the right flank and unleashing an unstoppable rising left-foot drive that flew across keeper Talbert Shumba and into the top corner.

Driven on by Keita, Guinea created several more good chances, the best of which saw Mamadou Diallo denied by Shumba’s sprawling save following a scramble in the box.

However, Zimbabwe held out to claim their first Nations Cup win since 2006, although they still finish bottom of Group B.

Mukansanga showed six yellow cards in total but, having previously refereed at the Tokyo Olympics last year, looked assured throughout her landmark outing in the Stade Ahmadou Ahidjo.

Source: Modern Ghana

Lethargic Black Stars fails to qualify from group stage after 3-2 defeat to Comoros in 2021 AFCON tourney

The senior national team, the Black Stars have been crashed out of the ongoing 2021 Africa Cup of Nations [AFCON] in Cameroon.

The West African country were beaten 3-2 by debutants Comoros Islands at Garoua’s Roumde Adjia Stadium to finish bottom of Group C with just a single point.

El Fardou Ben Mohamed scored Comoros’ first ever goal at the continental finals before Ahmed Mogni added a second just past the hour-mark.

Goals from Richmond Boakye and Alexander Djiku levelled the game up for Ghana, but Mogni grabbed a winner for the tiny island nation with five minutes remaining.

It is the first time in their history that Ghana have failed to win at least one pool stage match having made 22 past visits to the finals, their cause has not helped in Garoua by playing for 65 minutes with 10 men after a harsh early red card for lead striker Dede Ayew.

Morocco topped Group C with seven points, followed by Gabon on five, who also advance to the second round.

Comoros have an outside chance of being among the best third-placed finishers, though their minus two-goal difference will likely count against them.

Source: Modern Ghana